Effects In Blepharospasm, the effects should appear within three days and peak after three weeks. For pediatric cerebral palsy applications, the expectation is improvement within four weeks of the injection. The effects vary for glabellar wrinkles due to the usually individualized dosages.
Precautions There is the possibility of reactions at the site of an injection, and effects beyond the injection site, including but not limited to asthenia, generalized muscle weakness, diplopia, ptosis, dysphagia, dysphonia, dysarthria, urinary incontinence and breathing difficulties. Serious hypersensitivity has been reported as rare. There is a caution for people with pre-existing neuromuscular disorders, and for those with corneal exposure and ulceration in blepharospasm. Botulium Toxin Type A is not to be administered at all if a patient has a known allergy to any of the ingredients, or if the patients have neuromuscular junctional disorders or known to have adverse reactions. They should not be administered while taking muscle relaxants and some antibiotics. Further, the actual effects of prolonged use are not entirely explored. There is also additional advice for the specific therapeutic conditions mentioned, as this description is not comprehensive.